Diabetes management and preventive care vary significantly across genders, with disparities impacting health outcomes. This study analyzes gender-based differences in diabetes self-management, preventive care participation, and associated health risks, using data from the US Chronic Disease Indicators (CDI) dataset (2013 Release) and Python as means for analysis. The analysis highlights key trends, including variations in participation rates for preventive screenings, prevalence of depressive disorders, and the intersection of high blood pressure, cholesterol levels, and self-management behaviors. These findings illuminate critical gaps, particularly in mental health support for women, who often face higher rates of depressive disorders linked to chronic conditions. The results emphasize the importance of developing tailored, gender-specific strategies that address these disparities to improve overall diabetes care and health equity.